Focusing on the phenomenon of missing and murdered Indigenous women and girls, this chapter examines the fundamental role that femicide against Indigenous (First Nations, Métis, and Inuit) women and girls has and continues to play in securing Canada’s existence as a colonial nation state. While documenting how colonial white supremacist and heteropatriarchal domination is achieved through this femicide, this chapter also outlines Indigenous women’s resistance and resilience in the face of this violence. Finally, this chapter details how the Government of Canada has engaged with Indigenous women’s efforts, looking specifically at the work of the Native Women’s Association of Canada and the National Inquiry into Missing and Murdered Indigenous Women and Girls.